![]() ![]() A balanced Th1 (IFN-γ, TNF-α, IL-2, and IL-12) and Th2 (IL-4, IgG1) type of responses were observed following vaccination in both S. haematobium-hamster infection/challenge model. DNA prime/protein boost (1 + 1 dose administered on a single day) resulted in 26.95% reduction in worm burden in S. Immunization with Sm-p80 vaccine reduced worm burden by 46.75% against S. We also elucidated the expression of Sm-p80 and Sm-p80 ortholog proteins in different developmental stages of S. haematobium challenge infections in rodent models. In this study, we evaluated the cross-species protective efficacy of Sm-p80 vaccine against S. mansoni challenge infections in mice and baboons. Schistosoma mansoni large subunit of calpain ( Sm-p80)-based vaccine formulations have shown remarkable efficacy in protecting against S. Despite large-scale schistosomiasis control efforts, clear limitations such as possible emergence of drug resistance and reinfection rates highlight the need for an effective schistosomiasis vaccine. Schistosomiasis remains a major global health problem. Molehin, Adebayo J Sennoune, Souad R Zhang, Weidong Rojo, Juan U Siddiqui, Arif J Herrera, Karlie A Johnson, Laura Sudduth, Justin May, Jordan Siddiqui, Afzal A ![]() Cross-species prophylactic efficacy of Sm-p80-based vaccine and intracellular localization of Sm-p80/ Sm-p80 ortholog proteins during development in Schistosoma mansoni, Schistosoma japonicum, and Schistosoma haematobium.
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